Objectives: To conduct a systematic review and meta-analysis regarding the efficacy and safety of inhaled corticosteroids for COPD exacerbationsin HIV-positive patients. Methods We performed a search of Cochrane's register of trials using the key terms 'corticosteroids', 'copeldiaphragm', 'cortical fibrosis', (corticostical) and (corticosteroid) in order to identify all trials and eligible studies published between October 1, 2008, and February 2, 2011. Key words and search terms included were (CCHRT), HIV, (CCHRT), bronchitis, HIV and (HIV), testoviron-e 300 review. After exclusion of studies that had an unknown outcome or no significant differences from placebo on the primary outcome, we conducted a search in PubMed and EMBASE for non-English original titles/articles and unpublished manuscripts. One of the authors (JL) extracted eligibility information into data analysis form, and all studies meeting eligibility criteria were eligible to be included, testoviron 300 review. An analysis of cumulative risk (odds of a trial group achieving at least one of the primary outcome measures) was carried out, pharmaqo npp review. The primary outcome measures (defined as a measure of mortality and severe symptoms) were defined on the basis of the most recent assessment from the study in question and were compared with the outcome of interest (defined as a measure of survival) in the primary analysis. In the combined analysis, participants in the corticosteroids group demonstrated significantly greater relative efficacy in the primary outcome measure (HR, 0.86; 95% CI, 0.83-0.95; Figure A). In the combined analysis, COPD exacerbations in those receiving corticosteroids were significantly more likely to lead to mortality (1, testoviron 300 review.3%; 95% CI, 1, testoviron 300 review.1-2, testoviron 300 review.0; Figure B), testoviron 300 review. Cumulative risk in the study was slightly decreased in those receiving corticosteroids (relative risk, 0, 300 testoviron-e review.86; 95% CI, 0, 300 testoviron-e review.83-0, 300 testoviron-e review.93; Figure C), 300 testoviron-e review. Figure A: Cumulative risk of COPD exacerbations (the primary outcome measure) in HIV-positive patients (P=0.01, log-rank test). Figure B: Cumulative risk (as a percentage of the total study sample) of COPD exacerbations in HIV-positive patients (P=0, test depot 300 sis.05, log-rank test), test depot 300 sis. Figure C: Cumulative risk (as a percentage of the total study sample) of severe symptoms (the primary outcome measure) (P=0.0002, log-rank test).
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