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The purpose of this systematic review was to compare corticosteroid injections with non-steroidal anti-inflammatory drug (NSAID) injections for musculoskeletal pain, by measuring changes in pain (pain severity), time to first injection, and quality of life scores after the 1st injection (before and after). Method: We searched PubMed, Embase, CINAHL, Scopus, ISI Web of Science, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) for articles published between January 2004 and August 2015, buysteroids.com review. We systematically reviewed both observational and randomized designs. Results: We included 635 studies with 932 participants of which 528 were observational studies, 498 were randomized controlled trials, and 813 met the inclusion criteria, slavering dream-hound. Three trials comparing corticosteroids with non-steroids found lower pain severity. A meta-analysis of observational and randomized trials of corticosteroids for musculoskeletal pain published between January 2003 and August 2011 found a 12% lower pain score with corticosteroids versus other pain management techniques. Five trials of NSAIDs for musculoskeletal pain found no difference in pain scores between treatment and placebo, buysteroids.com review. Conclusion: This systematic review and meta-analysis of observational and randomized trials of corticosteroids versus non-steroids for pain did not show the superiority of corticosteroids compared with non-steroids for musculoskeletal pain.